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    CTAG1A cancer/testis antigen 1A [ Homo sapiens (human) ]

    Gene ID: 246100, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CTAG1Aprovided by HGNC
    Official Full Name
    cancer/testis antigen 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:24198
    See related
    Ensembl:ENSG00000268651 MIM:300657; AllianceGenome:HGNC:24198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESO1; CT6.1; LAGE-2; LAGE2A; NY-ESO-1
    Summary
    The protein encoded by this gene is a tumor cell antigen found in various types of cancers, which makes it a good candidate for a cancer vaccine. This gene is also highly expressed in normal ovary and testis tissues. An identical copy of this gene is found on the same chromosome. [provided by RefSeq, Dec 2015]
    Expression
    Restricted expression toward testis (RPKM 4.4) See more
    Orthologs
    all
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    Genomic context

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    Location:
    Xq28
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154585133..154586816)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152821564..152823242)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153813397..153815075)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 223 member A Neighboring gene activating transcription factor 4 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153825347-153825934 Neighboring gene cancer/testis antigen 1B Neighboring gene activating transcription factor 4 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Evaluation of cellular immune responses in cancer vaccine recipients: lessons from NY-ESO-1. Cebon J, et al. Expert Rev Vaccines, 2010 Jun. PMID 20518717
    2. Screening for biomarkers of spermatogonia within the human testis: a whole genome approach. von Kopylow K, et al. Hum Reprod, 2010 May. PMID 20208059
    3. Expression and Prognostic Significance of PD-L1 and NY-ESO1 in Gallbladder Carcinoma. Ibukić A, et al. In Vivo, 2023 Jul-Aug. PMID 37369470, Free PMC Article
    4. Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid tumors. Hashimoto K, et al. Medicine (Baltimore), 2023 Jun 2. PMID 37266606, Free PMC Article
    5. The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. Satie AP, et al. Lab Invest, 2002 Jun. PMID 12065688

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression and Prognostic Significance of PD-L1 and NY-ESO1 in Gallbladder Carcinoma.
      Title: Expression and Prognostic Significance of PD-L1 and NY-ESO1 in Gallbladder Carcinoma.
    2. Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid tumors.
      Title: Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid tumors.
    3. Expression may represent potential targets for cancer immunotherapy in patients with non small cell lung carcinoma.
      Title: Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    cancer/testis antigen 1
    Names
    New York Esophageal Squamous Cell Carcinoma 1
    autoimmunogenic cancer/testis antigen NY-ESO-1
    cancer/testis antigen 1-A
    cancer/testis antigen 6.1
    l antigen family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139250.2 → NP_640343.1  cancer/testis antigen 1

      See identical proteins and their annotated locations for NP_640343.1

      Status: REVIEWED

      Source sequence(s)
      AC244090
      Consensus CDS
      CCDS44025.1
      UniProtKB/Swiss-Prot
      A1L417, B7WNL9, P78358, Q7LBY4, Q9NY13
      Related
      ENSP00000469441.1, ENST00000599837.3
      Conserved Domains (1) summary
      pfam09341
      Location:92 → 162
      Pcc1; Transcription factor Pcc1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      154585133..154586816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      152821564..152823242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78358.1 GenPept UniProtKB/Swiss-Prot:P78358

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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